CD70 antibody

Catalog No. ABIN3024472

This anti-CD70 antibody is a Mouse Monoclonal antibody detecting CD70 in ELISA, FACS, IP, IF, IHC (fro) and InhA. Suitable for Human.

Quick Overview for CD70 antibody (ABIN3024472)

Target: CD70 (CD70 Molecule (CD70))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD70 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Inhibition Assay (InhA)

Clone: BU69

Product Details anti-CD70 Antibody

Purification: Protein G affinity chromatography

Immunogen: The human WM-1 (Waldenstrom s macroglobulinemia) cell line was used as the immunogen for the CD70 antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal dilution of the CD70 antibody should be determined by the researcher.

1. This mAb blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells.\. ELISA (order Ab without BSA),Functional Activity: Inhibits T cell proliferation induced by dendritic cells (Order SAF formulation) (1),Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL,Immunoprecipitation: 0.5-1 μg/500 μg protein lysate,Immunohistochemistry (Frozen): 0.5-1 μg/mL for 30 min at RT

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the CD70 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for CD70

Target: CD70 (CD70 Molecule (CD70))

Alternative Name: CD70

Background: CD70 belongs to the tumor necrosis factor (TNF) ligand family. It is a cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

Pathways: Cancer Immune Checkpoints