PDE7B antibody (N-Term)

Catalog No. ABIN302520

The Rabbit Polyclonal anti-PDE7B antibody (ABIN302520) specifically detects PDE7B in IHC (p). The antibody is reactive with Human samples.

Quick Overview for PDE7B antibody (N-Term) (ABIN302520)

Target: PDE7B (phosphodiesterase 7B (PDE7B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE7B antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PDE7B Antibody

Binding Specificity: N-Term

Specificity: This antibody detects Phosphodiesterase 7B (PDE7B) near N-terminus.

Purification: Immunoaffinity chromatography

Immunogen: PDE7B antibody was raised against synthetic peptide from near N-terminus of human PDE7B.

Application Details

Application Notes: Immunohistochemistry on paraffin sections (10 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Target Details for PDE7B

Target: PDE7B (phosphodiesterase 7B (PDE7B))

Alternative Name: PDE7B

Background: Phosphodiesterase 7B, a cAMP-specific phosphodiesterase, has been shown to affect cAMP-mediated neural activity and cAMP metabolism in the brain. PDE7B activity is inhibited by dipyridamole, IBMX, and SCH51866. At least three splice variants have been isolated for PDE7B from rats and they show tissue specific expression patterns.Synonyms: 5'-cyclic phosphodiesterase 7B, MGC88256, Phosphodiesterase 7B, cAMP-specific 3', rolipram-insensitive phosphodiesterase type 7

Gene ID: 27115

NCBI Accession: NP_061818

UniProt: Q9NP56

Pathways: cAMP Metabolic Process