PDE9A antibody
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- Target See all PDE9A Antibodies
- PDE9A (phosphodiesterase 9A (PDE9A))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PDE9A antibody is un-conjugated
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- This antibody detects Phosphodiesterase 9A (PDE9A) at internal domain.
- Purification
- Immunoaffinity chromatography
- Immunogen
- PDE9A antibody was raised against synthetic peptide from human PDE9A.
- Top Product
- Discover our top product PDE9A Primary Antibody
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- Application Notes
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Immunohistochemistry on paraffin sections (20 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.09 % sodium azide as preservative
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.
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- Target
- PDE9A (phosphodiesterase 9A (PDE9A))
- Alternative Name
- PDE9A (PDE9A Products)
- Synonyms
- PDE9A antibody, MGC116558 antibody, Pde9a antibody, HSPDE9A2 antibody, PDE9A1 antibody, phosphodiesterase 9A antibody, phosphodiesterase 9A S homeolog antibody, high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A antibody, PDE9A antibody, pde9a.S antibody, Pde9a antibody, LOC100549810 antibody, pde9a antibody
- Background
- Phosphodiesterase 9A is a cGMP-specific phosphodiesterase. PDE9A activity is inhibited by zaprinast, but it is insensitive to rolipram, vinpocetine, SKF-94120, dipyridamole, and IBMX. More than 20 alternatively spliced variants have been reported (Rentero et al. 2003). PDE9A has been implicated in penile erectile dysfunction, as well as in functional disturbances in which intraneuronal signal transmission via second messengers are important in the pathophysiology (example, bipolar affective disorder). PDE9A is the only cGMP-specific PDE with significant expression in the forebrain, and as such is likely to function in NO-cGMP signaling.Synonyms: 5'-cyclic phosphodiesterase 9A, HSPDE9A2, High affinity cGMP-specific 3', Phosphodiesterase 9A, Phosphodiesterase PDE9A21
- Gene ID
- 5152
- NCBI Accession
- NP_001001567
- UniProt
- O76083
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