IL-24 antibody (AA 100-150)

Catalog No. ABIN302672

The Rabbit Polyclonal anti-IL-24 antibody has been validated for WB, IHC (p) and FACS. It is suitable to detect IL-24 in samples from Human.

Quick Overview for IL-24 antibody (AA 100-150) (ABIN302672)

Target: IL-24 (IL24) (Interleukin 24 (IL24))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-24 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-IL-24 Antibody

Binding Specificity: AA 100-150

Specificity: This antibody recognizes Interleukin 24 (IL24/Mda-7).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Protein G Chromatography

Immunogen: A portion of amino acids 100-150 of human IL-24 was used as the immunogen.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry. Western Blot: 0.5-3 μg/mL. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS, 0.05 % Sodium Azide, 0.2 % Gelatin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C to -70 °C for longer.

Target Details for IL-24

Target: IL-24 (IL24) (Interleukin 24 (IL24))

Alternative Name: Interleukin-24 / IL24

Background: Interleukin 24 (IL-24)/melanoma differentiation-associated gene-7 (mda-7) encodes a secreted protein that exhibits significant homology to the interleukin 10 (IL-10) family of cytokines. The human IL-24 is secreted by activated peripheral blood mononuclear cells and binds two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2 resulting in the activation of JAK/STAT signaling pathways. Mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.Synonyms: IL-24, MDA7, Melanoma differentiation-associated gene 7 protein, ST16, Suppression of tumorigenicity 16 protein

Gene ID: 11009

NCBI Accession: NP_001172085

UniProt: Q13007

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Autophagy