IER3 antibody (Center)

Catalog No. ABIN302818

Product Details anti-IER3 Antibody

Target: IER3 (Immediate Early Response 3 (IER3))

Binding Specificity: Center

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IER3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: A 24 amino acid peptide near the center of Human IEX1.

Cross-Reactivity (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide - KLH conjugated corresponding to a 24 amino acid peptide near the center of Human IEX1

Isotype: IgG

Application Details

Application Notes: Western Blot: 2-4 μg/mL. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE!!

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for IER3

Target: IER3 (Immediate Early Response 3 (IER3))

Alternative Name: IER3 / IEX1 (IER3 Products)

Synonyms: DIF-2 antibody, DIF2 antibody, GLY96 antibody, IEX-1 antibody, IEX-1L antibody, IEX1 antibody, PRG1 antibody, AI663993 antibody, cI-3 antibody, gly96 antibody, IER3 antibody, Dif2 antibody, Iex1 antibody, Ler3 antibody, Prg1 antibody, immediate early response 3 antibody, IER3 antibody, Ier3 antibody

Background: IEX-1 was originally characterized as a gene induced by ultraviolet radiation and TNF-alpha, which protected human squamous carcinoma cells from apoptosis. Subsequent transfection studies have also shown that expression of IEX-1 in human keratinocytes and mouse fibroblasts results in more rapid proliferation of the cells as compared with controls. The IEX-1 promoter contains binding motifs for both NFKB and p53, suggesting that these proteins may regulate its expression. IEX-1 expression may be modulated by AML1 and TPO.Synonyms: DIF2, Differentiation-dependent gene 2 protein, GLY96, IEX-1, Immediate early protein GLY96, Immediate early response 3 protein, PACAP-responsive gene 1 protein, PRG1, Radiation-inducible immediate-early gene IEX-1

Gene ID: 8870

NCBI Accession: NP_003888

UniProt: P46695

Pathways: Regulation of Carbohydrate Metabolic Process