TCP1 alpha/CCTA antibody (AA 311-680)

Catalog No. ABIN3029088

This anti-TCP1 alpha/CCTA antibody is a Rabbit Polyclonal antibody detecting TCP1 alpha/CCTA in WB, ICC and IHC (p). Suitable for Human.

Quick Overview for TCP1 alpha/CCTA antibody (AA 311-680) (ABIN3029088)

Target: TCP1 alpha/CCTA (TCP1) (T-Complex 1 (TCP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCP1 alpha/CCTA antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TCP1 alpha/CCTA Antibody

Binding Specificity: AA 311-680

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 311-680) was used as the immunogen for this p63 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the p63 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the p63 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for TCP1 alpha/CCTA

Target: TCP1 alpha/CCTA (TCP1) (T-Complex 1 (TCP1))

Alternative Name: p63

Background: Tumor protein p63 (TP63), also known as TP73L is a protein that in humans is encoded by the TP63 gene. It is a member of the p53 family of transcription factors. This gene encodes for two main isoforms by alternative promoters (TAp63 and dNp63). TP63 has been mostly restricted to its apoptotic function and more recently as the guardian of oocyte integrity. It has been found that the combined loss of TP63 and p73 results in the failure of cells containing functional p53 to undergo apoptosis in response to DNA damage. It is an essential regulator of stem cell maintenance in stratified epithelial tissues. TP63 is also critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis.

UniProt: Q9H3D4