CD40 antibody (AA 1-360)

Catalog No. ABIN3030398

The Rabbit Polyclonal anti-CD40 antibody has been validated for WB and IHC (p). It is suitable to detect CD40 in samples from Human and Rat.

Quick Overview for CD40 antibody (AA 1-360) (ABIN3030398)

Target: CD40

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD40 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CD40 Antibody

Binding Specificity: AA 1-360

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 1-360) was used as the immunogen for this p50 antibody.

Isotype: IgG

Application Details

Application Notes: Titration of the p50 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: The p50 antibody can be stored at 4°C to -20°C. After reconstitution, aliquot and store at -20°C. Avoid repeat freeze/thaws.

Target Details for CD40

Target: CD40

Alternative Name: p50

Background: Nuclear factor NF-kappa-B p105/p50, also called EBP-1 is a protein that in humans is encoded by the NFKB1 gene. By fluorescence in situ hybridization, the gene was assigned to human chromosome 4q24. NFKB1 is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NFKB1 proteins by p105 and generation of p50 by a cotranslational processing.

Gene ID: 4790

Pathways: NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints