CXCR4 antibody (AA 31-43)

Catalog No. ABIN3030515

The Rabbit Polyclonal anti-CXCR4 antibody has been validated for WB. It is suitable to detect CXCR4 in samples from Human.

Quick Overview for CXCR4 antibody (AA 31-43) (ABIN3030515)

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCR4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CXCR4 Antibody

Binding Specificity: AA 31-43

Purification: Antigen affinity

Immunogen: Amino acids 31-43 (EENANFNKIFLPT) were used as the immunogen for this CXCR4 antibody.

Isotype: IgG

Application Details

Application Notes: Titration of the CXCR4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the CXCR4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for CXCR4

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Alternative Name: CXCR4

Background: Chemokine,CXC Motif, Receptor 4, also known as FUSIN or NPY3R, is a protein that in humans is encoded by the CXCR4 gene. By PCR analysis of human/hamster hybrid cell DNA, Herzog et al.(1993) showed that the NPY3R gene is located on human chromosome 2. Feng et al.(1996) showed that transient expression of the gene allowed nonhuman cells coexpressing recombinant CD4 to undergo Env-CD4-mediated cell fusion and productive HIV-1 infection. Peled et al.(1999) demonstrated that SDF1 and its receptor CXCR4 are critical for murine bone marrow engraftment by human SCID repopulating stem cells. Treatment of human cells with anti-CXCR antibodies prevented engraftment.

UniProt: P61073

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events