Claudin 5 antibody (AA 191-218)

Catalog No. ABIN3030536

The Rabbit Polyclonal anti-Claudin 5 antibody has been validated for WB. It is suitable to detect Claudin 5 in samples from Human and Rat.

Quick Overview for Claudin 5 antibody (AA 191-218) (ABIN3030536)

Target: Claudin 5 (CLDN5)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Claudin 5 Antibody

Binding Specificity: AA 191-218

Purification: Antigen affinity

Immunogen: Amino acids 191-218 (RPDLSFPVKYSAPRRPTATGDYDKKNYV-human) were used as the immunogen for the Claudin-5 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Claudin 5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Claudin 5 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Claudin 5

Target: Claudin 5 (CLDN5)

Alternative Name: Claudin 5

Background: Claudin-5, also known as BEC1, is a protein that in humans is encoded by the CLDN5 gene. By use of yeast artificial chromosomes, Claudin-5 is localized between polymorphic markers D22S944 and D22S941 on chromosome 22q11, both of which are deleted in more than 80 % of VCFS patients. This gene encodes a member of the claudin family. Family members are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Additionally, it plays a major role in tight junction-specific obliteration of the intercellular space.

Gene ID: 7122

Pathways: Hepatitis C