Integrin alpha 1 antibody (C-Term)

Catalog No. ABIN3031361

The Rabbit Polyclonal anti-Integrin alpha 1 antibody has been validated for WB and IHC (p). It is suitable to detect Integrin alpha 1 in samples from Human, Mouse and Rat. There is 1 publication available.

Quick Overview for Integrin alpha 1 antibody (C-Term) (ABIN3031361)

Target: Integrin alpha 1 (ITGA1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Integrin alpha 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Integrin alpha 1 Antibody

Binding Specificity: C-Term

Purification: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human Integrin alpha 1 (SNQKRELAIQISKD) was used as the immunogen for this Integrin alpha 1 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Integrin alpha 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Integrin alpha 1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

References for anti-Integrin alpha 1 antibody (ABIN3031361)

Bayer, Svensson, Schjerling, Williams, Wasserman, Kjaer: "Influence of the integrin alpha-1 subunit and its relationship with high-fat diet upon extracellular matrix synthesis in skeletal muscle and tendon." in: Cell and tissue research, Vol. 381, Issue 1, pp. 177-187, (2020) (PubMed).

Target Details for Integrin alpha 1

Target: Integrin alpha 1 (ITGA1)

Alternative Name: Integrin alpha 1

Background: Integrin alpha 1(ITGA1) chain associates with the beta 1(ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.

UniProt: P56199

Pathways: EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex