KIT Ligand antibody (AA 26-44)

Catalog No. ABIN3031560

This anti-KIT Ligand antibody is a Rabbit Polyclonal antibody detecting KIT Ligand in WB and IHC (p). Suitable for Human.

Quick Overview for KIT Ligand antibody (AA 26-44) (ABIN3031560)

Target: KIT Ligand (KITLG)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIT Ligand antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-KIT Ligand Antibody

Binding Specificity: AA 26-44

Purification: Antigen affinity

Immunogen: Amino acids 26-44 (DEGICRNRVTNNVKDVTKLV-human) were used as the immunogen for this SCF antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the SCF antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the SCF antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for KIT Ligand

Target: KIT Ligand (KITLG)

Alternative Name: SCF

Background: Stem Cell Factor (also called kit-ligand, KL1, and Steel factor) is a cytokine that binds to the c-Kit receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. It is localized to the long arm of human chromosome 12, between 12q14.3 and 12qter. SCF plays a role in the regulation of HSCs in the stem cell niche in the bone marrow. It has been shown to increase the survival of HSCs in vitro and contributes to the self renewal and maintenance of HSCs in-vivo. HSCs at all stages of development express the same levels of the receptor for SCF (c-Kit). The stromal cells that surround HSCs are a component of the stem cell niche, and they release a number of ligands, including SCF.

UniProt: P21583

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway