Lamin B2 antibody (AA 580-597)

Catalog No. ABIN3031588

This Rabbit Polyclonal antibody specifically detects Lamin B2 in WB, IHC (p) and IHC (fro). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Lamin B2 antibody (AA 580-597) (ABIN3031588)

Target: Lamin B2 (LMNB2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin B2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Lamin B2 Antibody

Binding Specificity: AA 580-597

Purification: Antigen affinity

Immunogen: Amino acids 580-597 (EEDLFHQQGDPRTTSRGC) were used as the immunogen for this Lamin B2 antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Application Details

Application Notes: Titration of the Lamin B2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: The lyophilized Lamin B2 antibody can be stored at 4°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Lamin B2

Target: Lamin B2 (LMNB2)

Alternative Name: Lamin B2

Background: Lamin B2, also called LMNB2, is a protein associated with laminopathies. The LMNB2 gene is mapped to the G-negative subtelomeric band p13.3 of chromosome 19 by in situ hybridization. Model organisms have been used in the study of Lamin B2 function. A conditional knockout mouse line, called Lmnb2, was generated as part of the International Knockout Mouse Consortium program-a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. A highly sensitive procedure about mapping the start site of DNA replication in a 13.7-kb region of human chromosome 19 coding for lamin B2 is developed for the identification of the origin of bidirectional DNA synthesis in single-copy replicons of mammalian cells.

UniProt: Q03252

Pathways: Apoptosis, Caspase Cascade in Apoptosis