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PROC antibody (AA 446-461)

PROC Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3032367
  • Target See all PROC Antibodies
    PROC (Vitamin K-dependent protein C (PROC))
    Binding Specificity
    • 8
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 446-461
    Reactivity
    • 88
    • 12
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 68
    • 16
    • 8
    • 3
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 71
    • 27
    • 1
    Polyclonal
    Conjugate
    • 61
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This PROC antibody is un-conjugated
    Application
    • 60
    • 48
    • 31
    • 20
    • 15
    • 9
    • 8
    • 8
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    Antigen affinity
    Immunogen
    Amino acids 446-461 (HGHIRDKEAPQKSWAP) were used as the immunogen for this Protein C antibody.
    Isotype
    IgG
    Top Product
    Discover our top product PROC Primary Antibody
  • Application Notes
    The stated application concentrations are suggested starting amounts. Titration of the Protein C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the Protein C antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    PROC (Vitamin K-dependent protein C (PROC))
    Alternative Name
    Protein C (PROC Products)
    Synonyms
    proc antibody, si:ch1073-188c16.3 antibody, zgc:63987 antibody, PROC antibody, APC antibody, PC antibody, PROC1 antibody, THPH3 antibody, THPH4 antibody, proc1 antibody, MGC64425 antibody, PA antibody, protein C, inactivator of coagulation factors Va and VIIIa antibody, protein C (inactivator of coagulation factors Va and VIIIa), a antibody, protein C (inactivator of coagulation factors Va and VIIIa) antibody, protein C, inactivator of coagulation factors Va and VIIIa S homeolog antibody, vitamin K-dependent protein C antibody, prosaposin antibody, protein C antibody, proline rich protein HaeIII subfamily 1 antibody, PROC antibody, proca antibody, proc.S antibody, proc antibody, CpipJ_CPIJ000393 antibody, CpipJ_CPIJ002754 antibody, CpipJ_CPIJ003717 antibody, CpipJ_CPIJ003718 antibody, CpipJ_CPIJ014440 antibody, CpipJ_CPIJ018032 antibody, CpipJ_CPIJ018737 antibody, PSAP antibody, Proc antibody, PRH1 antibody
    Target Type
    Viral Protein
    Background
    Protein C (PROC), also called PC, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The PROC gene is mapped on 2q14.3. The PROC gene contains 8 exons and spans about 11 kb by Foster et al. The conversion of Protein C to a protease with anticoagulant function by thrombin requires as a cofactor thrombomodulin, an endothelial cell membrane protein. Riewald et al. demonstrated that activated Protein C uses the endothelial cell protein C receptor as a coreceptor for cleavage of protease-activated receptor-1 on endothelial cells. Faust et al. demonstrated that the endothelial pathways required for Protein C activation are impaired in severe meningococcal sepsis. They stated that improvement in the outcome of children with meningococcal sepsis who were treated with unactivated Protein C concentrates had been described in case reports and in one uncontrolled series.
    UniProt
    P04070
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