SLC22A6 antibody (AA 534-550)

Catalog No. ABIN3032684

The Rabbit Polyclonal anti-SLC22A6 antibody has been validated for WB and IHC (p). It is suitable to detect SLC22A6 in samples from Human and Rat.

Quick Overview for SLC22A6 antibody (AA 534-550) (ABIN3032684)

Target: SLC22A6 (Solute Carrier Family 22 Member 6 (SLC22A6))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC22A6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SLC22A6 Antibody

Binding Specificity: AA 534-550

Purification: Antigen affinity

Immunogen: Amino acids 534-550 (QKYMVPLQASAQEKNGL-human) were used as the immunogen for this SLC22A6 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the SLC22A6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the SLC22A6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for SLC22A6

Target: SLC22A6 (Solute Carrier Family 22 Member 6 (SLC22A6))

Alternative Name: SLC22A6

Background: Solute carrier family 22 (organic anion transporter), member 6, also called OAT1 or PAHT, is a protein that in humans is encoded by the SLC22A6 gene, which is also a member of the organic anion transporter (OAT) family of proteins. It is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport. Along with OAT3, OAT1/SLC22A6 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys. The protein functions as organic anion exchanger. When the uptake of one molecule of an organic anion is transported into a cell by an SLC22A6 exchanger, one molecule of an endogenous dicarboxylic acid(such as glutarate, ketoglutarate, etc) is simultaneously transported out of the cell.

UniProt: Q4U2R8

Pathways: Dicarboxylic Acid Transport