Unc5c antibody (C-Term)

Catalog No. ABIN3042323

The Rabbit Polyclonal anti-Unc5c antibody has been validated for WB and FACS. It is suitable to detect Unc5c in samples from Human, Mouse and Rat.

Quick Overview for Unc5c antibody (C-Term) (ABIN3042323)

Target: Unc5c (Unc-5 Homolog C (C. Elegans) (Unc5c))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Unc5c antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-Unc5c Antibody

Binding Specificity: AA 894-930, C-Term

Purpose: Anti-UNC5C Antibody Picoband®

Sequence: DLWEAQNFPD GNLSMLAAVL EEMGRHETVV SLAAEGQ

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-UNC5C Antibody Picoband® (ABIN3042323). Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human UNC5C, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry(Fixed), 1-3 μg/1x10⁶ cells, Human
1. "Entrez Gene: UNC5C unc-5 homolog C (C. elegans)". 2. Ackerman SL, Knowles BB (Dec 1998). "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23".Genomics 52 (2): 205-8. 3. Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M (May 1997). "Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors". Nature 386 (6627): 833-8.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for Unc5c

Target: Unc5c (Unc-5 Homolog C (C. Elegans) (Unc5c))

Alternative Name: UNC5C

Background:

Synonyms: Netrin receptor UNC5C,Protein unc-5 homolog 3,Protein unc-5 homolog C,UNC5C,UNC5H3,

Tissue Specificity: Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung. .

Background: Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene. This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediates the repellent response to netrin, they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.

Molecular Weight: 115 kDa

Gene ID: 8633

UniProt: O95185