BCL10 antibody (AA 1-233)

Catalog No. ABIN3042330

This anti-BCL10 antibody is a Rabbit Polyclonal antibody detecting BCL10 in WB and IHC. Suitable for Human.

Quick Overview for BCL10 antibody (AA 1-233) (ABIN3042330)

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-BCL10 Antibody

Binding Specificity: AA 1-233

Purpose: Anti-Bcl10 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Bcl10 Antibody Picoband® (ABIN3042330). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Bcl10 recombinant protein (Position: M1-Q233). Human Bcl10 shares 91% and 91.4% amino acid (aa) sequence identity with mouse and rat Bcl10, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
1. Ruland, J., Duncan, G. S., Elia, A., del Barco Barrantes, I., Nguyen, L., Plyte, S., Millar, D. G., Bouchard, D., Wakeham, A., Ohashi, P. S., Mak, T. W.Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappa-B and neural tube closure.Cell 104: 33-42, 2001. 2. Willis, T. G., Jadayel, D. M., Du, M.-Q., Peng, H., Perry, A. R., Abdul-Rauf, M., Price, H., Karran, L., Majekodunmi, O., Wlodarska, I., Pan, L., Crook, T., Hamoudi, R., Isaacson, P. G., Dyer, M. J. S.Bcl10 is involved in t(1,14)(p22,q32) of MALT B cell lymphoma and mutated in multiple tumor typesCell 96: 35-45, 1999. 3. Xue, L., Morris, S. W., Orihuela, C., Tuomanen, E., Cui, X., Wen, R., Wang, D.Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells.Nature Immun. 4: 857-865, 2003.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for BCL10

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Alternative Name: BCL10

Background:

Synonyms: B-cell lymphoma/leukemia 10,B-cell CLL/lymphoma 10,Bcl-10,CARD-containing molecule enhancing NF-kappa-B,CARD-like apoptotic protein,hCLAP,CED-3/ICH-1 prodomain homologous E10-like regulator,CIPER,Cellular homolog of vCARMEN,cCARMEN,Cellular-E10,c-E10,Mammalian CARD-containing adapter molecule E10,mE10,BCL10,CIPER, CLAP,

Tissue Specificity: Ubiquitous.

Background: BCL10, B-cell CLL/lymphoma 10, gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The BCL10 gene is mapped to chromosome 1p22. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. And this protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Sequence Similarities: Contains 1 CARD domain.

Molecular Weight: 28 kDa

Gene ID: 8915

UniProt: O95999

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins