FMO1 antibody (C-Term)

Catalog No. ABIN3042396

This anti-FMO1 antibody is a Rabbit Polyclonal antibody detecting FMO1 in WB. Suitable for Human, Mouse and Rat.

Quick Overview for FMO1 antibody (C-Term) (ABIN3042396)

Target: FMO1 (Flavin Containing Monooxygenase 1 (FMO1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FMO1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FMO1 Antibody

Binding Specificity: AA 334-363, C-Term

Purpose: Anti-FMO1 Antibody Picoband®

Sequence: AFPFLDESVV KVEDGQASLY KYIFPAHLQK

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-FMO1 Antibody Picoband® (ABIN3042396). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human FMO1, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. "Entrez Gene: FMO1 flavin containing monooxygenase 1". 2. Cashman JR (2004). "The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development".Drug Discov. Today 9 (13): 574-581. 3. Dolphin C, Shephard EA, Povey S et al. (1991). "Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1)".J. Biol. Chem. 266 (19): 12379-85.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for FMO1

Target: FMO1 (Flavin Containing Monooxygenase 1 (FMO1))

Alternative Name: FMO1

Background:

Synonyms: Dimethylaniline monooxygenase [N-oxide-forming] 1,1.14.13.8,Dimethylaniline oxidase 1,Fetal hepatic flavin-containing monooxygenase 1,FMO 1,FMO1,

Tissue Specificity: Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine.

Background: Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene.

Sequence Similarities: Belongs to the FMO family.

Molecular Weight: 60 kDa

Gene ID: 2326

UniProt: Q01740