Kallikrein 4 antibody (AA 31-254)

Catalog No. ABIN3042476

Product Details anti-Kallikrein 4 Antibody

Target: Kallikrein 4 (KLK4) (Kallikrein-Related Peptidase 4 (KLK4))

Binding Specificity: AA 31-254

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Kallikrein 4 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Anti-Kallikrein 4/KLK4 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Kallikrein 4/KLK4 Antibody Picoband® (ABIN3042476). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Kallikrein 4 recombinant protein (Position: I31-S254).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
1. Klokk, T. I., Kilander, A., Xi, Z., Waehre, H., Risberg, B., Danielson, H. E., Saatcioglu, F. Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer. Cancer Res. 67: 5221-5230, 2007. 2. Nelson PS, Gan L, Ferguson C, Moss P, Gelinas R, Hood L, Wang K (March 1999). 3. Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD (June 2000).

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for Kallikrein 4

Target: Kallikrein 4 (KLK4) (Kallikrein-Related Peptidase 4 (KLK4))

Alternative Name: KLK4 (KLK4 Products)

Background:

Synonyms: Kallikrein-4,3.4.21.-,Enamel matrix serine proteinase 1,Kallikrein-like protein 1,KLK-L1,Prostase,Serine protease 17,KLK4,EMSP1, PRSS17, PSTS,

Tissue Specificity: Expressed in prostate.

Background: Kallikrein-related peptidase 4, also known as PSTS or EMSP1, is a protein which in humans is encoded by the KLK4 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. In particular, they may serve as biomarkers for both prostate cancer and breast cancer. It has been found that KLK4 is a proliferative factor with effects on gene expression and it may have a role in prostate cancer development and progression.

Sequence Similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.

Molecular Weight: 27 kDa

Gene ID: 9622

UniProt: Q9Y5K2

Pathways: Complement System