AVPR1A antibody (Middle Region)

Catalog No. ABIN3042582

This anti-AVPR1A antibody is a Rabbit Polyclonal antibody detecting AVPR1A in WB. Suitable for Human, Rat and Mouse.

Quick Overview for AVPR1A antibody (Middle Region) (ABIN3042582)

Target: AVPR1A (Arginine Vasopressin Receptor 1A (AVPR1A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AVPR1A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-AVPR1A Antibody

Binding Specificity: AA 155-173, Middle Region

Purpose: Anti-Vasopressin V1a receptor AVPR1A Antibody Picoband®

Sequence: HPLKTLQQPA RRSRLMIAT

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Vasopressin V1a receptor AVPR1A Antibody (ABIN3042582). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of rat AVPR1A, different from the related human and mouse sequences by one amino acid.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1. Birnbaumer, M. Vasopressin receptors. Trends Endocr. Metab. 11: 406-410, 2000. 2. Caldwell HK, Lee HJ, Macbeth AH, Young WS (2008). "Vasopressin: behavioral roles of an 'original' neuropeptide". Prog Neurobiol 84 (1): 1-24.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for AVPR1A

Target: AVPR1A (Arginine Vasopressin Receptor 1A (AVPR1A))

Alternative Name: AVPR1A

Background:

Synonyms: Vasopressin V1a receptor;V1aR;AVPR V1a;Antidiuretic hormone receptor 1a;Vascular/hepatic-type arginine vasopressin receptor;Avpr1a;

Tissue Specificity: Localized within gonadotropes of the anterior pituitary of the brain. Broadly distributed throughout the cerebral cortex. .

Background: Arginine vasopressin receptor 1A (officially called AVPR1A) is one of the three major receptor types for arginine vasopressin  (AVPR1B and AVPR2 being the others). It belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. This gene is mapped to 12q14.2. AVPR1A is present throughout the brain, as well as in the periphery, in the liver, kidney, and vasculature. The protein encoded by this gene acts as receptor for arginine vasopressin. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis.

Sequence Similarities: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Molecular Weight: 47 kDa

UniProt: P30560

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Response to Water Deprivation, Regulation of Carbohydrate Metabolic Process