TNFRSF11A antibody (N-Term)

Catalog No. ABIN3042604

Product Details anti-TNFRSF11A Antibody

Target: TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))

Binding Specificity: AA 29-44, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFRSF11A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 11A(TNFRSF11A) detection. Tested with WB, IHC-P in Human.

Sequence: QIAPPCTSEK HYEHLG

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 11A(TNFRSF11A) detection. Tested with WB, IHC-P in Human.
Gene Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Protein Name: Tumor necrosis factor receptor superfamily member 11A

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human RANK(29-44aa QIAPPCTSEKHYEHLG).

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TNFRSF11A

Target: TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))

Alternative Name: TNFRSF11A (TNFRSF11A Products)

Synonyms: RANK antibody, RGD1563614 antibody, TNFRSF11A antibody, Ly109 antibody, ODFR antibody, OFE antibody, Rank antibody, TRANCE-R antibody, mRANK antibody, CD265 antibody, FEO antibody, LOH18CR1 antibody, OPTB7 antibody, OSTS antibody, PDB2 antibody, TRANCER antibody, TNF receptor superfamily member 11A antibody, TNF receptor superfamily member 11a antibody, tumor necrosis factor receptor superfamily, member 11a, NFKB activator antibody, Tnfrsf11a antibody, TNFRSF11A antibody

Background: Receptor Activator of Nuclear Factor K B(RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling. RANKL(Receptor Activator for Nuclear Factor K B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al.(1997) mapped the RANK gene to 18q22.1.

Synonyms: Activator of NFKB antibody|CD 265 antibody|CD265 antibody|CD265 antigen antibody|EOF antibody|FEO antibody|LOH18CR1 antibody|Loss of heterozygosity 18 chromosomal region 1 antibody|mRANK antibody|NFKB activator antibody|ODFR antibody|OFE antibody|OPTB7 antibody|Osteoclast differentiation factor receptor antibody|OSTS antibody|PDB 2 antibody|PDB2 antibody|RANK antibody|Receptor activator of NF KB antibody|Receptor activator of NF-KB antibody|receptor activator of nuclear factor kappa B antibody|TNFRSF 11A antibody|TNFRSF11A antibody|TNFSF11 antibody|TNR11_HUMAN antibody|TRANCE R antibody|TRANCER antibody|Tumor necrosis factor receptor superfamily member 11a NFKB activator antibody|Tumor necrosis factor receptor superfamily member 11a activator of NFKB antibody|Tumor Necrosis Factor Receptor Superfamily Member 11a antibody

UniProt: Q9Y6Q6

Pathways: NF-kappaB Signaling