PLG antibody (AA 103-352)

Catalog No. ABIN3042791

The Rabbit Polyclonal anti-PLG antibody has been validated for WB, ELISA and IHC. It is suitable to detect PLG in samples from Human.

Quick Overview for PLG antibody (AA 103-352) (ABIN3042791)

Target: PLG (Plasminogen (PLG))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLG antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PLG Antibody

Binding Specificity: AA 103-352

Purpose: Anti-Angiostatin K1-3/PLG Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Angiostatin K1-3/PLG Antibody (ABIN3042791). Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Angiostatin K1-3 recombinant protein (Position: C103-C352).

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
Western blot, 0.1-0.5 μg/mL, Human
1. Forsgren, M., Raden, B., Israelsson, M., Larsson, K., Heden, L.-O. Molecular cloning and characterization of a full-length cDNA clone for human plasminogen. FEBS Lett. 213: 254-260, 1987. 2. Miyata, T., Iwanaga, S., Sakata, Y., Aoki, N. Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site. Proc. Nat. Acad. Sci. 79: 6132-6136, 1982.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide. Carrier free (No BSA)

Preservative: Sodium azide, Without preservative

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for PLG

Target: PLG (Plasminogen (PLG))

Alternative Name: PLG

Background:

Synonyms: Plasminogen,3.4.21.7,Plasmin heavy chain A,Activation peptide,Angiostatin,Plasmin heavy chain A, short form,Plasmin light chain B,PLG,

Tissue Specificity: Present in plasma and many other extracellular fluids. It is synthesized in the liver.

Background: Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth. It displays increased inhibitory activity (ED50 = 70nM) relative to kringles 1-4 (ED50 = 135nM).

Sequence Similarities: Belongs to the peptidase S1 family. Plasminogen subfamily.

Molecular Weight: 95 kDa

UniProt: P00747

Pathways: Complement System, Lipid Metabolism