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Survivin antibody (AA 1-142)

This anti-Survivin antibody is a Rabbit Polyclonal antibody detecting Survivin in WB, ELISA and IHC. Suitable for Human. This Primary Antibody has been cited in 8+ publications.
Catalog No. ABIN3042792

Quick Overview for Survivin antibody (AA 1-142) (ABIN3042792)

Target

See all Survivin (BIRC5) Antibodies
Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Reactivity

  • 130
  • 58
  • 48
  • 1
  • 1
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  • 1
Human

Host

  • 98
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Rabbit

Clonality

  • 93
  • 49
Polyclonal

Conjugate

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  • 2
  • 2
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  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
This Survivin antibody is un-conjugated

Application

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • Binding Specificity

    • 20
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    • 5
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    • 4
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    AA 1-142

    Purpose

    Anti-survivin/BIRC5 Antibody Picoband®

    Cross-Reactivity (Details)

    No cross-reactivity with other proteins

    Characteristics

    Anti-survivin/BIRC5 Antibody (ABIN3042792). Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Purification

    Immunogen affinity purified.

    Immunogen

    E. coli-derived human Survivin recombinant protein (Position: M1-D142).

    Isotype

    IgG
  • Application Notes

    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Ambrosini, G., Adida, C., Altieri, D. C.A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma.Nature Med. 3: 917-921, 1997. 2. Chantalat, L., Skoufias, D. A., Kleman, J.-P., Jung, B., Dideberg, O., Margolis, R. L.Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions.Molec. Cell 6: 183-189, 2000.

    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Concentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

    Handling Advice

    Avoid repeated freezing and thawing.

    Storage

    4 °C,-20 °C

    Storage Comment

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Gu, Ren, Wang, Qu, Zhang: "Expression of livin, survivin and caspase-3 in prostatic cancer and their clinical significance." in: International journal of clinical and experimental pathology, Vol. 8, Issue 11, pp. 14034-9, (2016) (PubMed).

    Zhang, Wang, Yang, Pan, Li, Yuan: "Preclinical pharmacodynamic evaluation of antibiotic nitroxoline for anticancer drug repurposing." in: Oncology letters, Vol. 11, Issue 5, pp. 3265-3272, (2016) (PubMed).

    Li, Zhao, Lu, Li, Yang, Wu, Liu: "Notch-1 signaling promotes the malignant features of human breast cancer through NF-?B activation." in: PLoS ONE, Vol. 9, Issue 4, pp. e95912, (2014) (PubMed).

    Zhang, Lu, Hou, Hu, Wang: "The effects of STAT3 and Survivin silencing on the growth of human bladder carcinoma cells." in: Tumour biology, Vol. 35, Issue 6, pp. 5401-7, (2014) (PubMed).

    Chen, Xie, Zhao, Wang, Bai, Yin, Jiang, Xie, Jia, Huang et al.: "Ampelopsin induces apoptosis by regulating multiple c?Myc/S?phase kinase?associated protein 2/F?box and WD repeat?containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma ..." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 105-12, (2014) (PubMed).

    Li, Zhang, Fang, Yan, Zhao, Feng, Ma, Ye: "Aspirin overcomes Navitoclax-resistance in hepatocellular carcinoma cells through suppression of Mcl-1." in: Biochemical and biophysical research communications, Vol. 434, Issue 4, pp. 809-14, (2013) (PubMed).

    Cai, Liu, Zhao, Wan, Hu, Zhou, Chen: "Expressions of survivin and vascular endothelial growth factor in a Murine model of proliferative retinopathy." in: International journal of ophthalmology, Vol. 5, Issue 3, pp. 293-6, (2012) (PubMed).

    Wang, Lu, Song, Liu, Xu: "Radiosensitivity of human colon cancer cell enhanced by immunoliposomal docetaxel." in: World journal of gastroenterology, Vol. 11, Issue 26, pp. 4003-7, (2005) (PubMed).

  • Target

    Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

    Alternative Name

    BIRC5

    Background

    Synonyms: Baculoviral IAP repeat-containing protein 5,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,BIRC5,API4, IAP4,

    Tissue Specificity: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines. .

    Background: Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin gene contains 4 exons. The survivin gene is mapped to chromosome 17q25 by pulsed field gel electrophoresis and single- and 2-color FISH. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells.

    Sequence Similarities: Belongs to the IAP family.

    Molecular Weight

    16 kDa

    UniProt

    O15392

    Pathways

    Apoptosis, Cell Division Cycle, Nuclear Hormone Receptor Binding
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