SERPINC1 antibody (N-Term)

Catalog No. ABIN3042828

This anti-SERPINC1 antibody is a Rabbit Polyclonal antibody detecting SERPINC1 in WB. Suitable for Human, Mouse and Rat.

Quick Overview for SERPINC1 antibody (N-Term) (ABIN3042828)

Target: SERPINC1 (Serpin Family C Member 1 (SERPINC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SERPINC1 Antibody

Binding Specificity: AA 93-107, N-Term

Purpose: Anti-Antithrombin III/SERPINC1 Antibody Picoband®

Sequence: TFYQHLADSK NDNDN

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Antithrombin III/SERPINC1 Antibody (ABIN3042828). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Antithrombin III, different from the related mouse and rat sequences by one amino acid.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1. Baud, O., Picard, V., Durand, P., Duchemin, J., Proulle, V., Albenc-Gelas, M., Devictor, D., Dreyfus, M. Intracerebral hemorrhage associated with a novel antithrombin gene mutation in a neonate. J. Pediat. 139: 741-743, 2001. 2. Fischer, A. M., Cornu, P., Sternberg, C., Meriane, F., Dautzenberg, M. D., Chafa, O., Beguin, S., Desnos, M. Antithrombin III Alger: a new homozygous AT III variant. Thromb. Haemost. 55: 218-221, 1986.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SERPINC1

Target: SERPINC1 (Serpin Family C Member 1 (SERPINC1))

Alternative Name: SERPINC1

Background:

Synonyms: Antithrombin-III,ATIII,Serpin C1,SERPINC1,AT3,PRO0309,

Tissue Specificity: Found in plasma.

Background: Serpin peptidase inhibitor, clade C (antithrombin), member 1, also known as Antithrombin III (AT3) is the most important inhibitor of thrombin OMBIN III and other coagulation proteinases. This gene is mapped to 1q25.1. The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.

Sequence Similarities: Belongs to the serpin family.

Molecular Weight: 57 kDa

UniProt: P01008