AQP6 antibody (C-Term)

Catalog No. ABIN3042906

This anti-AQP6 antibody is a Rabbit Polyclonal antibody detecting AQP6 in WB and IHC. Suitable for Human.

Quick Overview for AQP6 antibody (C-Term) (ABIN3042906)

Target: AQP6 (Aquaporin 6, Kidney Specific (AQP6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AQP6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-AQP6 Antibody

Binding Specificity: AA 264-282, C-Term

Purpose: Anti-Aquaporin 6/AQP6 Antibody Picoband®

Sequence: EPLKKESQPG SGAVEMESV

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Aquaporin 6/AQP6 Antibody (ABIN3042906). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Aquaporin 6.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. "Entrez Gene: Aquaporin 6, kidney specific". Retrieved 2012-04-10 2. Ma, T., Yang, B., Umenishi, F., Verkman, A. S. Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. Genomics 43: 387-389, 1997. 3. Liu, K., Kozono, D., Kato, Y., Agre, P., Hazama, A., Yasui, M. Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution. Proc. Nat. Acad. Sci. 102: 2192-2197, 2005.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for AQP6

Target: AQP6 (Aquaporin 6, Kidney Specific (AQP6))

Alternative Name: AQP6

Background:

Synonyms: Aquaporin-6,AQP-6,Aquaporin-2-like,Kidney-specific aquaporin,hKID,AQP6,AQP2L,

Background: Aquaporin 6, kidney specific is a protein in humans that is encoded by the AQP6 gene. The aquaporins (AQPs) are a family of water-transporting proteins that facilitate osmotically driven water movement across cell plasma membranes. Among the seven human aquaporins cloned to date (AQPs 0-6), genes encoding the four most closely related aquaporins (AQP0, AQP2, AQP5, and AQP6) have been mapped to chromosome band 12q13, suggesting an aquaporin family gene cluster at this locus. Unlike other aquaporins, AQP6 functions not as a water channel but as an anion-selective channel. Single-channel analyses have shown AQP6 to flicker rapidly between closed and open status.

Molecular Weight: 142 kDa

UniProt: Q13520