CCL26 antibody (C-Term)

Catalog No. ABIN3043210

This Rabbit Polyclonal antibody specifically detects CCL26 in WB. It exhibits reactivity toward Human.

Quick Overview for CCL26 antibody (C-Term) (ABIN3043210)

Target: CCL26 (Chemokine (C-C Motif) Ligand 26 (CCL26))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCL26 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CCL26 Antibody

Binding Specificity: AA 73-94, C-Term

Purpose: Anti-Eotaxin 3/CCL26 Antibody Picoband®

Sequence: CTHPRKKWVQ KYISLLKTPK QL

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Eotaxin 3/CCL26 Antibody (ABIN3043210). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Eotaxin 3.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
1. Guo, R.-F., Ward, P. A., Hu, S.-M., McDuffie, J. E., Huber-Lang, M., Shi, M. M.Molecular cloning and characterization of a novel human CC chemokine, SCYA26.Genomics 58: 313-317, 1999. 2. Kitaura, M., Suzuki, N., Imai, T., Takagi, S., Suzuki, R., Nakajima, T., Hirai, K., Nomiyama, H., Yoshie, O.Molecular cloning of a novel human CC chemokine (eotaxin-3) that is a functional ligand of CC chemokine receptor 3.J. Biol. Chem. 274: 27975-27980, 1999. 3. Nakayama, T., Watanabe, Y., Oiso, N., Higuchi, T., Shigeta, A., Mizuguchi, N., Katou, F., Hashimoto, K., Kawada, A., Yoshie, O.Eotaxin-3/CC chemokine ligand 26 is a functional ligand for CX3CR1.J. Immun. 185: 6472-6479, 2010.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CCL26

Target: CCL26 (Chemokine (C-C Motif) Ligand 26 (CCL26))

Alternative Name: CCL26

Background:

Synonyms: C-C motif chemokine 26,CC chemokine IMAC,Eotaxin-3,Macrophage inflammatory protein 4-alpha,MIP-4-alpha,Small-inducible cytokine A26,Thymic stroma chemokine-1,TSC-1,CCL26,SCYA26,UNQ216/PRO242,

Tissue Specificity: Ubiquitously expressed at low levels in various tissues including heart and ovary.

Background: Eotaxin-3 is a small cytokine belonging to the CC chemokine family that is also called CCL26, Chemokine (C-C motif) ligand 26. Chemokines play pivotal roles in health and disease by controlling migration and tissue localization of specific types of cells expressing their cognate receptors. Eotaxin-3 is chemotactic for eosinophils and basophils and elicits its effects by binding to the cell surface chemokine receptor CCR3. It is expressed by several tissues including heart, lung and ovary, and in endothelial cells that have been stimulated with the cytokine interleukin 4. This gene for chemokine is located on human chromosome 7. Eotaxin-3 induced migration of eosinophils and basophils only at a 10-fold higher concentration than eotaxin.

Sequence Similarities: Belongs to the intercrine beta (chemokine CC) family.

Molecular Weight: 11 kDa

UniProt: Q9Y258

Pathways: Regulation of Actin Filament Polymerization