SOCS4 antibody (AA 291-440)

Catalog No. ABIN3043346

The Rabbit Polyclonal anti-SOCS4 antibody has been validated for WB. It is suitable to detect SOCS4 in samples from Human.

Quick Overview for SOCS4 antibody (AA 291-440) (ABIN3043346)

Target: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SOCS4 Antibody

Binding Specificity: AA 291-440

Purpose: Anti-SOCS4 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-SOCS4 Antibody Picoband® (ABIN3043346). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SOCS4 recombinant protein (Position: M291-C440). Human SOCS4 shares 98% amino acid (aa) sequence identity with mouse SOCS4.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
1. Bullock AN, Rodriguez MC, Debreczeni JE, Songyang Z, Knapp S. ""Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation"". Structure, 2007 Nov. 2. Kobayashi D, Nomoto S, Kodera Y, Fujiwara M, Koike M, Nakayama G, Ohashi N, Nakao A. ""Suppressor of cytokine signaling 4 detected as a novel gastric cancer suppressor gene using double combination array analysis"". World J Surg, 2012 Feb.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for SOCS4

Target: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Alternative Name: SOCS4

Background:

Synonyms: Suppressor of cytokine signaling 4,SOCS-4,Suppressor of cytokine signaling 7,SOCS-7,SOCS4,SOCS7,

Tissue Specificity: Placenta, liver, and to a much smaller extent, in lung.

Background: SOCS4, also known as Suppressor of cytokine signaling 4, is mapped to 14q22.1. The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Sequence Similarities: Contains 1 SH2 domain.

Molecular Weight: 51 kDa

Gene ID: 122809

Pathways: JAK-STAT Signaling, EGFR Signaling Pathway