BIRC7 antibody (AA 87-298)

Catalog No. ABIN3043512

This anti-BIRC7 antibody is a Rabbit Polyclonal antibody detecting BIRC7 in WB and ELISA. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for BIRC7 antibody (AA 87-298) (ABIN3043512)

Target: BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIRC7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-BIRC7 Antibody

Binding Specificity: AA 87-298

Purpose: Anti-Livin/BIRC7 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Livin/BIRC7 Antibody (ABIN3043512). Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Livin recombinant protein (Position: E87-S298). Human Livin shares 69.8% amino acid (aa) sequence identity with mouse Livin.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, -
ELISA, 0.1-0.5 μg/mL, -
1. "Entrez Gene: BIRC7 baculoviral IAP repeat-containing 7 (livin)". 2. Kasof GM, Gomes BC (May 2001). "Livin, a novel inhibitor of apoptosis protein family member". J Biol Chem 276 (5): 3238-46. 3. Lin JH, Deng G, Huang Q, Morser J (Feb 2001). "KIAP, a novel member of the inhibitor of apoptosis protein family". Biochem Biophys Res Commun 279 (3): 820-31.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

References for anti-BIRC7 antibody (ABIN3043512)

Guo, Gao, Zhang, Jing, Liu, Shi, Zhai, Jing, Du: "Expression and clinical significance of livin protein in hepatocellular carcinoma." in: Disease markers, Vol. 35, Issue 5, pp. 489-96, (2014) (PubMed).

Target Details for BIRC7

Target: BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))

Alternative Name: BIRC7

Background:

Synonyms: Baculoviral IAP repeat-containing protein 7,6.3.2.-,Kidney inhibitor of apoptosis protein,KIAP,Livin,Melanoma inhibitor of apoptosis protein,ML-IAP,RING finger protein 50,Baculoviral IAP repeat-containing protein 7 30 kDa subunit,Truncated livin,p30-Livin,tLivin,BIRC7,KIAP, LIVIN, MLIAP, RNF50,UNQ5800/PRO19607/PRO21344,

Tissue Specificity: Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.

Background: Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene. This protein is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) and a RING finger motif. Its gene is mapped to 20q13.3. It has got 280- and 298- amino acids. The protein is highly expressed in melanomas while lowly expressed in some lymphomas, fetal kidney, fetal liver, testis and thymus. BIRC7 plays a vital role in blocking apoptosis induced.

Sequence Similarities: Belongs to the IAP family.

Molecular Weight: 33 kDa

Gene ID: 79444