AAMP antibody (AA 235-434)

Catalog No. ABIN3043736

The Rabbit Polyclonal anti-AAMP antibody is suitable to detect AAMP in samples from Human. It has been validated for WB, FACS and IHC.

Quick Overview for AAMP antibody (AA 235-434) (ABIN3043736)

Target: AAMP (Angio-Associated, Migratory Cell Protein (AAMP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AAMP antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)

Product Details anti-AAMP Antibody

Binding Specificity: AA 235-434

Purpose: Anti-AAMP CCL18 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-AAMP CCL18 Antibody (ABIN3043736). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human AAMP recombinant protein (Position: E235-R434).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for AAMP

Target: AAMP (Angio-Associated, Migratory Cell Protein (AAMP))

Alternative Name: AAMP

Background:

Synonyms: C-C motif chemokine 18,Alternative macrophage activation-associated CC chemokine 1,AMAC-1,CC chemokine PARC,Dendritic cell chemokine 1,DC-CK1,Macrophage inflammatory protein 4,MIP-4,Pulmonary and activation-regulated chemokine,Small-inducible cytokine A18,CCL18 (1-68),CCL18 (3-69),CCL18 (4-69),CCL18,AMAC1, DCCK1, MIP4, PARC, SCYA18,

Tissue Specificity: Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid. .

Background: AAMP, also known as Angio-associated, migratory cell protein, is a protein which in humans is encoded by the AAMP gene. It is mapped to 2q35. The gene product of AAMP is an immunoglobulin-type protein, which is found to be expressed strongly in endothelial cells, cytotrophoblasts, and poorly differentiated colon adenocarcinoma cells found in lymphatics. It has been demonstrated that an AAMP peptide containing the putative heparan sulfate-binding domain binds to heparin and mediates heparin-sensitive cell adhesion. AAMP plays a role in angiogenesis and cell migration. In smooth muscle cell migration, it may act through the RhoA pathway.

Sequence Similarities: Contains 8 WD repeats.

Molecular Weight: 52 kDa

Gene ID: 14

UniProt: P55774

Pathways: Smooth Muscle Cell Migration