Tenascin R antibody (N-Term)

Catalog No. ABIN3044266

Product Details anti-Tenascin R Antibody

Target: Tenascin R (TNR) (Tenascin R (Restrictin, Janusin) (TNR))

Binding Specificity: AA 104-117, N-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tenascin R antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Purpose: Anti-Tenascin-R TNR Antibody Picoband®

Sequence: QTSDHESQVT FTHK

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Tenascin-R TNR Antibody (ABIN3044266). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of mouse TNR, identical to the related rat sequence, and different from the related human sequence by one amino acid.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat, Human, Mouse
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Leprini, A., Gherzi, R., Siri, A., Querze, G., Viti, F., Zardi, L.The human tenascin-R gene.J. Biol. Chem. 271: 31251-31254, 1996. 2. Saghatelyan, A., de Chevigny, A., Schachner, M., Lledo, P.-M.Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrain.Nature Neurosci. 7: 347-356, 2004. 3. Williams, H., Schachner, M., Wang, B., Kenwrick, S.Radiation hybrid mapping of the genes for tenascin-R (TNR), phosducin (PDC), Laminin C1 (LAMC1), and TAX in 1q25-q32.Genomics 46: 165-166, 1997.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Tenascin R

Target: Tenascin R (TNR) (Tenascin R (Restrictin, Janusin) (TNR))

Alternative Name: TNR (TNR Products)

Background:

Synonyms: Tenascin-R,TN-R,Janusin,Restrictin,TNR,

Tissue Specificity: Brain specific. .

Background: Tenascin-R is a protein that in humans is encoded by the TNR gene. Tenascin-R (TNR) is an extracellular matrix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion), TNX (TNXB), and TNR. The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues. TNR has been detected predominantly in the central nervous system and is localized around motor neurons and on motor axons in the spinal cord, cerebellum, hippocampus, and olfactory bulb. It is suggested that tenascin-R has a role in initiating the detachment of neuroblasts from tangential chains and in initiating radial migration of the cells.

Sequence Similarities: Belongs to the tenascin family.

Molecular Weight: 150 kDa

UniProt: Q92752

Pathways: Regulation of Cell Size