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HMMR antibody (C-Term)

HMMR Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3044455
  • Target See all HMMR Antibodies
    HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))
    Binding Specificity
    • 16
    • 14
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 706-724, C-Term
    Reactivity
    • 68
    • 28
    • 11
    Human
    Host
    • 59
    • 9
    Rabbit
    Clonality
    • 58
    • 10
    Polyclonal
    Conjugate
    • 25
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This HMMR antibody is un-conjugated
    Application
    • 49
    • 28
    • 25
    • 23
    • 13
    • 13
    • 11
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purpose
    Rabbit IgG polyclonal antibody for Hyaluronan mediated motility receptor(HMMR) detection. Tested with WB, IHC-P in Human.
    Sequence
    KEGNTNCYRA PMECQESWK
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Hyaluronan mediated motility receptor(HMMR) detection. Tested with WB, IHC-P in Human.
    Gene Name: hyaluronan-mediated motility receptor(RHAMM)
    Protein Name: Hyaluronan mediated motility receptor
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human CD168(706-724aa KEGNTNCYRAPMECQESWK).
    Isotype
    IgG
    Top Product
    Discover our top product HMMR Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Thimerosal (Merthiolate), Sodium azide
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Expiry Date
    12 months
  • Ozbilgin, Boz, Tuğyan, Inan, Vatansever: "RHAMM Expression in the Rat Endometrium during the Estrous Cycle and following Implantation." in: Journal of reproduction & infertility, Vol. 13, Issue 3, pp. 131-7, (2013) (PubMed).

  • Target
    HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))
    Alternative Name
    HMMR (HMMR Products)
    Synonyms
    AA386826 antibody, CD168 antibody, Rhamm antibody, RHAMM antibody, IHABP antibody, hyaluronan mediated motility receptor (RHAMM) antibody, hyaluronan-mediated motility receptor antibody, hyaluronan mediated motility receptor antibody, Hmmr antibody, HMMR antibody
    Background
    HMMR, Hyaluronan-mediated motility receptor, is a protein which in humans is encoded by the HMMR gene. RHAMM was originally discovered as a soluble protein that altered migratory cell behavior and bound to hyaluronan, HMMR is less well studied than the main hyaluronan(HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the endoplasmic reticulum/Golgi complex, HMMR does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence. HMMR normally is localized inside the cell and is only release by certain, poorly defined stimuli. The transport of HMMR to the extracellular space still is unclear but may involve transport channels or proteins, flippase activity, or exocytosis. Intracellularly, HMMR associates with microtubules and, working with BRCA1 and BARD1, plays a role in the regulation of mitosis. Extracellularly, HMMR associates with CD44, and upon binding to HA, activates intracellular signaling pathways. Variants of HMMR caused by alternative splicing have been observed, but not thoroughly studied.

    Synonyms: CD168 antibody|CD168 antigen antibody|HMMR antibody|HMMR_HUMAN antibody|Hyaluronan mediated motility receptor antibody|Hyaluronan-mediated motility receptor(RHAMM) antibody|IHABP antibody|Intracellular hyaluronic acid-binding protein antibody|MGC119494 antibody|MGC119495 antibody|OTTHUMP00000196920 antibody|Receptor for hyaluronan-mediated motility antibody|RHAMM antibody
    UniProt
    O75330
    Pathways
    Glycosaminoglycan Metabolic Process
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