Cathepsin K antibody (AA 115-329)

Catalog No. ABIN3044511

The Rabbit Polyclonal anti-Cathepsin K antibody (ABIN3044511) specifically detects Cathepsin K in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for Cathepsin K antibody (AA 115-329) (ABIN3044511)

Target: Cathepsin K (CTSK)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin K antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Cathepsin K Antibody

Binding Specificity: AA 115-329

Purpose: Anti-Cathepsin K/CTSK Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Cathepsin K/CTSK Antibody (ABIN3044511). Tested in IHC, WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Cathepsin K recombinant protein (Position: A115-M329). Human Cathepsin K shares 86.9% and 88.8% amino acid (aa) sequence identity with mouse and rat Cathepsin K, respectively.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for Cathepsin K

Target: Cathepsin K (CTSK)

Alternative Name: CTSK

Background:

Synonyms: Cathepsin K,3.4.22.38,Cathepsin O,Cathepsin O2,Cathepsin X,CTSK,CTSO, CTSO2,

Tissue Specificity: Predominantly expressed in osteoclasts (bones).

Background: Cathepsin K, abbreviated?CTSK, is an?enzyme?that in humans is encoded by the?CTSK?gene. It is mapped to 1q21. The protein encoded by this gene is a lysosomal?cysteine protease?involved in bone remodeling and resorption. And this protein, which is a member of the peptidase C1 protein family, is expressed predominantly in?osteoclasts. Additionally, the enzyme's ability to catabolize?elastin,?collagen, and?gelatin?allow it to break down?bone?and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil inemphysema. Cathepsin K?inhibitors, such as?odanacatib, show great potential in the treatment of?osteoporosis. Cathepsin K is degraded by Cathepsin S, called Controlled Cathepsin Cannibalism.

Molecular Weight: 45 kDa

Gene ID: 1513

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades