FcRn antibody (AA 56-291)

Catalog No. ABIN3044521

This Rabbit Polyclonal antibody specifically detects FcRn in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for FcRn antibody (AA 56-291) (ABIN3044521)

Target: FcRn (neonatal Fc Receptor (FcRn))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FcRn antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-FcRn Antibody

Binding Specificity: AA 56-291

Purpose: Anti-FCGRT Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-FCGRT Antibody Picoband® (ABIN3044521). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human FCGRT recombinant protein (Position: Q56-E291). Human FCGRT shares 70.2% and 68.9% amino acid (aa) sequence identity with mouse and rat FCGRT, respectively.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. Chaudhury C, Mehnaz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC, Anderson CL (February 2003). "The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan". J. Exp. Med. 197 (3): 315-22. 2. Junghans, R. P., Ebralidze, A., Tiwari, B. Does (CUG)n repeat in DMPK mRNA 'paint' chromosome 19 to suppress distant genes to create the diverse phenotype of myotonic dystrophy? A new hypothesis of long-range cis autosomal inactivation. Neurogenetics 3: 59-67, 2001. 3. Kandil E, Egashira M, Miyoshi O, Niikawa N, Ishibashi T, Kasahara M, Miyosi O (July 1996). "The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3". Cytogenet. Cell Genet. 73 (1-2): 97-8.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for FcRn

Target: FcRn (neonatal Fc Receptor (FcRn))

Alternative Name: FCGRT

Background:

Synonyms: IgG receptor FcRn large subunit p51,FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor,FCGRT,FCRN,

Tissue Specificity: Ubiquitous. Prominent expression in brain, lung, and liver. .

Background: IgG receptor FcRn large subunit p51?is a?protein?that in humans is encoded by the?FCGRT?gene. This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation.?In addition, it is postulated that long-range cis inactivation of the?FCGRT?gene is responsible for hypercatabolism of IgG in myotonic dystrophy. The?FCGRT?gene is closely situated to the DMPK gene, which is mutant in DM.?

Molecular Weight: 50 kDa

Gene ID: 2217

UniProt: P55899

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process