CXCL7 antibody (AA 55-128)

Catalog No. ABIN3044533

This Rabbit Polyclonal antibody specifically detects CXCL7 in WB, IHC, ELISA. It exhibits reactivity toward Human.

Quick Overview for CXCL7 antibody (AA 55-128) (ABIN3044533)

Target: CXCL7 (PPBP) (Pro-Platelet Basic Protein (Chemokine (C-X-C Motif) Ligand 7) (PPBP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCL7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-CXCL7 Antibody

Binding Specificity: AA 55-128

Purpose: Anti-NAP2/PPBP Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-NAP2/PPBP Antibody Picoband® (ABIN3044533). Tested in ELISA(Cap), IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived humn NAP2 recombinant protein (Position: S55-D128).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, -
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
ELISA(Cap) , 1-5 μg/mL, Human, -
1. "Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)". 2. Hristov M, Zernecke A, Bidzhekov K, et al. (March 2007). "Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury".Circ. Res. 100 (4): 590-7. 3. Majumdar S, Gonder D, Koutsis B, Poncz M (1991). "Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4". J Biol Chem 266 (9): 5785-9.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for CXCL7

Target: CXCL7 (PPBP) (Pro-Platelet Basic Protein (Chemokine (C-X-C Motif) Ligand 7) (PPBP))

Alternative Name: PPBP

Background:

Synonyms: Platelet basic protein;PBP;C-X-C motif chemokine 7;Leukocyte-derived growth factor;LDGF;Macrophage-derived growth factor;MDGF;Small-inducible cytokine B7;Connective tissue-activating peptide III;CTAP-III;LA-PF4;Low-affinity platelet factor IV;TC-2;Connective tissue-activating peptide III (1-81);CTAP-III (1-81);Beta-thromboglobulin;Beta-TG;Neutrophil-activating peptide 2 (74);NAP-2 (74);Neutrophil-activating peptide 2 (73);NAP-2 (73);Neutrophil-activating peptide 2;NAP-2;TC-1;Neutrophil-activating peptide 2 (1-66);NAP-2 (1-66);Neutrophil-activating peptide 2 (1-63);NAP-2 (1-63);PPBP;CTAP3, CXCL7, SCYB7, TGB1, THBGB1;

Tissue Specificity: Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. .

Background: Chemokine (C-X-C motif) ligand 7  (CXCL7), also known as NAP2 or Pro-Platelet basic protein  (PPBP), is a human gene. The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Furthermore, the protein is an antimicrobial protein with bactericidal and antifungal activity.

Molecular Weight: 19 kDa

Gene ID: 5473

UniProt: P02775