VSX2 antibody (N-Term)

Catalog No. ABIN306799

This Sheep Polyclonal antibody specifically detects VSX2 in WB and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for VSX2 antibody (N-Term) (ABIN306799)

Target: VSX2 (Visual System Homeobox 2 (VSX2))

Reactivity: Human

Host: Sheep

Clonality: Polyclonal

Conjugate: This VSX2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-VSX2 Antibody

Binding Specificity: N-Term

Specificity: Human Chx10 protein

Cross-Reactivity: Chicken, Human, Mouse, Rat

Characteristics: Ceh-10 homeodomain-containing homolog,Chx10 is a 46 kDa homeodomain protein of the paired-like class that is essential for development of the mammalian eye. Mutations in Chx10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina Chx10 is expressed in retinal progenitors, while in the mature retina, Chx10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the Chx10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. Chx10 is also expressed in the developing brainstem, thalamus, and spinal cord.

Immunogen: Antibody raised in sheep against a recombinant protein corresponding to amino acids 1 to 131 derived from the N-terminal region of the human Chx10 protein conjugated to KLH.

Isotype: IgG

Application Details

Application Notes: Detects Chx10 by Western blot at 0.5 to 1 μg/mL. Detects a 46 kDa band in mouse and rat retinal tissue lysates. Optimal concentration should be evaluated by serial dilutions. Suitable for use against recombinant proteins conjugated to OVA, GST, His tags and other.

Restrictions: For Research Use only

Handling

Buffer: Ammonium sulphate precipitated antibody in PBS with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for VSX2

Target: VSX2 (Visual System Homeobox 2 (VSX2))

Alternative Name: chx 10 (NT)

UniProt: P58304

Pathways: Dopaminergic Neurogenesis