CSAG2 antibody

Catalog No. ABIN307032

This anti-CSAG2 antibody is a Rabbit Polyclonal antibody detecting CSAG2 in WB and ELISA. Suitable for Human.

Quick Overview for CSAG2 antibody (ABIN307032)

Target: CSAG2 (CSAG Family, Member 2 (CSAG2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSAG2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CSAG2 Antibody

Cross-Reactivity: Human

Characteristics: Chondrosarcoma-associated protein 2, Taxol-resistant-associated protein 3, TRAG-3, CSAG2, TRAG3,The expression of the cancer-testis antigen Taxol resistance-associated gene-3 (TRAG-3) is associated with acquired paclitaxel (Taxol) resistance, and is expressed in a variety of cancers - e.g., breast cancer, leukemia, and melanoma. Overexpressed in taxol-resistant breast cancer line MDA 435(TR) and the doxorubicin-resistant multiple myelanoma lines 8226/Dox(40) and 8226/MDR(10)V. Weakly expressed in kidney. TRAG-3 is an attractive target for immunotherapy of cancer. First identified as a novel cancer/testis antigen, TRAG-3, (Taxol Resistance Associated Gene-3) was initially discovered in a search for new genes involved in drug resistance. Early studies of TRAG-3 revealed a minimal to absent expression in normal tissues and a marked over-expression in many carcinoma cell lines including several melanoma lines. By RT-PCR evaluation of TRAG-3 two transcripts are seen in many carcinoma cell lines with products in the the 799 bp and a second alternatively spliced transcript.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from the human Trag-3 protein.

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blotting (0.5-2 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for CSAG2

Target: CSAG2 (CSAG Family, Member 2 (CSAG2))

Alternative Name: Trag 3 (Taxol-resistant-associated protein 3)

UniProt: Q9Y5P2