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- Target See all Netrin 1 (NTN1) Antibodies
- Netrin 1 (NTN1)
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Netrin 1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Cross-Reactivity
- Cat, Cow, Human, Macaque, Mouse, Rat
- Characteristics
- Netrin 1, NTN1,Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis. Netrin 1s main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.
- Purification
- Ammonium Sulfate Precipitation
- Immunogen
- Synthetic peptide derived from the human Netrin 1 protein
- Isotype
- IgG
- Top Product
- Discover our top product NTN1 Primary Antibody
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anti-Netrin 1 (NTN1) (C-Term) antibody
Verified NTN1 Reactivity: Human ELISA, IF Host: Goat Polyclonal unconjugated
anti-Netrin 1 (NTN1) (AA 501-604) antibodyNTN1 Reactivity: Mouse, Rat WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Netrin 1 (NTN1) (C-Term) antibodyNTN1 Reactivity: Human, Mouse, Rat WB, IHC, ELISA, ICC, IF Host: Rabbit Polyclonal unconjugated
anti-Netrin 1 (NTN1) (AA 181-195), (Secreted) antibodyNTN1 Reactivity: Rat WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Netrin 1 (NTN1) (C-Term) antibodyNTN1 Reactivity: Human WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Netrin 1 (NTN1) (AA 186-478) antibodyNTN1 Reactivity: Human WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Netrin 1 (NTN1) (C-Term) antibodyNTN1 Reactivity: Human, Mouse, Rat, Monkey WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Netrin 1 (NTN1) (AA 568-596), (C-Term) antibodyNTN1 Reactivity: Human WB Host: Rabbit Polyclonal RB44404 unconjugated
anti-Netrin 1 (NTN1) antibodyMicroarray verified NTN1 Reactivity: Human IHC Host: Mouse Monoclonal MAB935839 unconjugated
anti-Netrin 1 (NTN1) antibodyMicroarray verified NTN1 Reactivity: Human IHC Host: Mouse Monoclonal MAB577874 unconjugated
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- Application Notes
- Antibody can be used for Western blotting (0.5-2 μg/mL). Optimal concentration should be evaluated by serial dilutions.
- Restrictions
- For Research Use only
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- Buffer
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- Target
- Netrin 1 (NTN1)
- Alternative Name
- Netrin 1 (NTN1 Products)
- NCBI Accession
- NP_004813
- Pathways
- Regulation of Cell Size
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