Netrin 1 antibody (NTN1)

Details for Product anti-NTN1 Antibody No. ABIN307033
Antigen
  • ntn1-A
  • Netrin-1
  • NTN1
  • unc-6
  • MGC147073
  • NTN1L
  • AI561871
  • BC019633
  • netrin-1
  • netrin 1 L homeolog
  • netrin 1
  • ntn1.L
  • NTN1
  • ntn1
  • Ntn1
Reactivity
Human, Mouse (Murine), Rat (Rattus), Cow (Bovine), Macaque, Cat (Feline)
81
73
52
9
6
5
5
3
1
1
Host
Rabbit
79
10
8
4
2
1
1
Clonality
Polyclonal
Conjugate
This Netrin 1 antibody is un-conjugated
7
6
2
2
2
2
2
2
2
1
1
1
1
1
Application
Western Blotting (WB)
70
34
32
18
13
13
9
8
7
4
4
2
Options
Isotype IgG
Plasmids, Primers & others Plasmids, Primers & others Netrin 1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Netrin 1 (NTN1 Antibody Abstract)
Background Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis. Netrin 1's main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity. Synonyms: Netrin 1, NTN1.
NCBI Accession NP_004813
Pathways Regulation of Cell Size
Application Notes Antibody can be used for Western blotting (0.5-2 ug/ml). Positive Control: Antibody tested on MDCKII cell lysates..
Restrictions For Research Use only
Concentration 1 mg/ml
Storage -20 °C
Supplier Images
Image no. 1 for anti-Netrin 1 (NTN1) antibody (ABIN307033) Ship at ambient temperature, freeze upon arrival Product should be stored at -20ºC....
Background publications Nguyen, Cai: "Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 17, pp. 6530-5, 2006 (PubMed).

Furne, Corset, Hérincs, Cahuzac, Hueber, Mehlen: "The dependence receptor DCC requires lipid raft localization for cell death signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 11, pp. 4128-33, 2006 (PubMed).

Furne, Mehlen: "[The deadly rafts: when lipid rafts regulate dependence receptors]." in: Médecine sciences : M/S, Vol. 22, Issue 11, pp. 909-10, 2006 (PubMed).

Nakamura, Takei, Goshima: "[Signaling mechanism connecting axon guidance molecules and growth cone cytoskeleton]." in: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Vol. 51, Issue 6 Suppl, pp. 733-41, 2006 (PubMed).

Chang, Adler, Krause, Clark, Gertler, Tessier-Lavigne, Bargmann: "MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin." in: Current biology : CB, Vol. 16, Issue 9, pp. 854-62, 2006 (PubMed).

Xie, Hong, Ma, Ren, Ackerman, Mei, Xiong: "DCC-dependent phospholipase C signaling in netrin-1-induced neurite elongation." in: The Journal of biological chemistry, Vol. 281, Issue 5, pp. 2605-11, 2006 (PubMed).

Shekarabi, Moore, Tritsch, Morris, Bouchard, Kennedy: "Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, Issue 12, pp. 3132-41, 2005 (PubMed).

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