LASS1 antibody (C-Term)

Catalog No. ABIN307129

This Rabbit Polyclonal antibody specifically detects LASS1 in WB. It exhibits reactivity toward Human.

Quick Overview for LASS1 antibody (C-Term) (ABIN307129)

Target: LASS1 (CERS1) (Ceramide Synthase 1 (CERS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LASS1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LASS1 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human

Characteristics: LAG1 longevity assurance homolog 1, UOG-1 protein, LAG1, LASS1,LAG1 is a longevity gene, the first such gene to be identified. Originally cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, LAC1, has been found in the yeast genome. The human homolog of LAG1 has functions in human aging. LAG1 may be involved in neurodegenerative diseases and human aging. Lass1 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner. Located in the endoplasmic reticulum membrane, LAss1 is a multi-pass membrane protein.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from the C-terminal human Lass1 protein.

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blotting (1-5 μg/mL starting dilution). Other uses not yet tested. Only reacts with human Lass1 protein. Does not cross react with other species. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for LASS1

Target: LASS1 (CERS1) (Ceramide Synthase 1 (CERS1))

Alternative Name: Lass1 (non-GDF1)

UniProt: P27544