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Cytochrome C antibody

This Mouse Monoclonal antibody specifically detects Cytochrome C in FACS and EIA. It exhibits reactivity toward Human, Rat, Mouse and Rabbit.
Catalog No. ABIN317119

Quick Overview for Cytochrome C antibody (ABIN317119)

Target

See all Cytochrome C (CYCS) Antibodies
Cytochrome C (CYCS) (Cytochrome C, Somatic (CYCS))

Reactivity

  • 202
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  • 5
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  • 1
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Human, Rat, Mouse, Rabbit

Host

  • 112
  • 107
  • 5
  • 1
Mouse

Clonality

  • 137
  • 87
  • 1
Monoclonal

Conjugate

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  • 2
  • 2
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  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
This Cytochrome C antibody is un-conjugated

Application

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  • 1
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Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone

2G8
  • Specificity

    This antiobdy recognises cytochrome c, originally termed Apaf-2, an evolutionarily conserved protein which acts as an essential mitochondrial electron carrier between respirable substrates and oxygen, during aerobic energy production. Clone 2G8 is reported to block the role of cytochrome c as a co-factor in the activation of caspase 9. Removal of sodium azide is recommended prior to use in functional assays

    Characteristics

    Synonyms: CYCS, CYC

    Purification

    Purified IgG prepared by affinity chromatography on Protein A

    Immunogen

    Human cytochrome c

    Isotype

    IgG1
  • Application Notes

    Flow Cytometry. ELISA.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Restrictions

    For Research Use only
  • Concentration

    1.0 mg/mL

    Buffer

    PBS containing 0.09 % Sodium Azide as preservative

    Preservative

    Sodium azide

    Precaution of Use

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C/-20 °C

    Storage Comment

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch. Caution: (A full Health and Safety assessment is available upon request) This product containsSodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled bytrained staff only.

    Expiry Date

    12 months
  • Target

    Cytochrome C (CYCS) (Cytochrome C, Somatic (CYCS))

    Alternative Name

    Cytochrome C

    Background

    A second major function for cytochrome c is its role as an intermediate in apoptosis, both through its association with inositol-3-phosphate receptor (IP3 receptor) which acts as an ER calcium release channel, and its association with apoptotic protease activating factor 1 (Apaf-1), resulting in the formation of the apoptosome protein complex which then recruits and activates pro-caspase 9 (Apaf-3).Synonyms: CYC, CYCS

    Gene ID

    54205

    UniProt

    P99999

    Pathways

    Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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