LTBR antibody (Extracellular Domain) (PE)

Catalog No. ABIN317402

This anti-LTBR antibody is a Rat Monoclonal antibody detecting LTBR in FACS. Suitable for Mouse.

Quick Overview for LTBR antibody (Extracellular Domain) (PE) (ABIN317402)

Target: LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This LTBR antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: 5G11b

Product Details anti-LTBR Antibody (PE)

Binding Specificity: Extracellular Domain

Specificity: This antibody recognises lymphotoxin-beta receptor (LT beta R), a member of the tumour necrosis factor family. LT beta R is primarily expressed on stromal cells and fibroblasts and at lower levels on myeloid cell lines. Clone 5G11b specifically recognises surface expressed LT beta R. The clone is reported to be agonistic with respect to NF Kappa B activation, MIP-2 induction and IL-6 release (2). This product is routinely tested on mouse WEHI cells.

Characteristics: Synonyms: Tumor necrosis factor receptor 3, TNF-R3, Tumor necrosis factor C receptor, TNFCR,TNFRSF3, D12S370, Lymphotoxin-beta receptor, Tumor necrosis factor receptor superfamilymember 3, Tumor necrosis factor receptor type III, Tumor necrosis factor receptor 2-relatedprotein

Purification: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogen: Recombinant extracellular domain of LT beta R

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry: use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Reconstitute with 1.0 mL distilled water

Concentration: 0.05 mg/mL

Buffer: Phosphate buffered saline pH 7.4, 0.09 % Sodium Azide, 1 % Bovine Serum Albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody prior and following reconstitution at 2-8 °C. DO NOT FREEZE. This product is photosensitive and should be protected from light.
Shelf life: One year from despatch.

Expiry Date: 12 months

Target Details for LTBR

Target: LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))

Alternative Name: LTBR / TNFR3

Background: The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin alpha and lymphtoxin beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.Synonyms: D12S370, Lymphotoxin-beta receptor, TNF-R3, TNFCR, TNFRSF3, Tumor necrosis factor C receptor, Tumor necrosis factor receptor 2-related protein, Tumor necrosis factor receptor 3, Tumor necrosis factor receptor superfamily member 3, Tumor necrosis factor receptor type III

Gene ID: 4055

UniProt: P36941

Pathways: NF-kappaB Signaling