CUX1 antibody

Catalog No. ABIN317667

The Rabbit Polyclonal anti-CUX1 antibody (ABIN317667) specifically detects CUX1 in WB, IF and IHC (p). The antibody is reactive with Human and Mouse samples.

Quick Overview for CUX1 antibody (ABIN317667)

Target: CUX1 (Cut-Like Homeobox 1 (CUX1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CUX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CUX1 Antibody

Specificity: This antibody detects endogenous levels of CDP protein.(region surrounding Gln24)

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1/40000-1/60000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CUX1

Target: CUX1 (Cut-Like Homeobox 1 (CUX1))

Alternative Name: CUTL1 / CDP

Background: CDP (for CCAAT displacement protein) was identified as a repressor for transcription of developmentally regulated genes. It is a homeodomain protein that appears to compete with transcriptional activating proteins for binding to the promoter regions of various genes. CDP contains three cut repeats which function as DNA binding domains. It has been demonstrated that cut repeat domains have the capacity to bind to DNA in conjunction with or independently of homeodomain DNA binding. CDP has been shown to be the DNA-binding subunit of the HiNF-D complex, which contains cyclin A, Cdc2 and an Rb-related protein in addition to CDP. Histone expression is required for the transition to S phase in the cell cycle. The HiNF-D complex regulates the transcription of Histone H4, H3 and H1 genes, allowing cells to progress from G1 to S phase.Synonyms: CCAAT displacement protein, CUX1, Homeobox protein cut-like 1

Molecular Weight: approx. 164 kDa

Gene ID: 1523

NCBI Accession: NP_001189472

UniProt: P39880

Pathways: Cellular Glucan Metabolic Process