LPAR3 antibody (Lysophosphatidic Acid Receptor 3)

Details for Product anti-LPAR3 Antibody No. ABIN317747
Antigen
  • EDG7
  • Edg-7
  • GPCR
  • HOFNH30
  • LP-A3
  • LPA3
  • RP4-678I3
  • Edg7
  • lpA3
  • lysophosphatidic acid receptor 3
  • LPAR3
  • LOC100038016
  • Lpar3
Reactivity
Human
101
56
45
3
2
2
2
2
2
1
1
Host
Rabbit
106
2
Clonality
Polyclonal
Conjugate
This LPAR3 antibody is un-conjugated
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
62
39
28
22
20
13
7
7
4
3
3
2
1
Options
Specificity EDG-7 antibody detects endogenous levels of EDG-7 protein.(region surrounding Pro324)
Purification Affinity chromatography
Plasmids, Primers & others Plasmids, Primers & others LPAR3 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name EDG-7 / LPAR3 (LPAR3 Antibody Abstract)
Background The EDG (endothelial differentiation gene) family of G protein-coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways.Synonyms: EDG7, Endothelial differentiation, GPCR, HOFNH3O, LPA-3, LPAR3, Lysophosphatidic acid receptor 3, Lysophosphatidic acid receptor Edg-7, lysophosphatidic acid G-protein coupled receptor 7
Molecular Weight approx. 47 kDa
Gene ID 23566
NCBI Accession NP_036284
UniProt Q9UBY5
Pathways Regulation of Cell Size
Application Notes ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1,0 mg/mL
Buffer Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Image no. 1 for anti-Lysophosphatidic Acid Receptor 3 (LPAR3) antibody (ABIN317747) anti-Lysophosphatidic Acid Receptor 3 (LPAR3) antibody
Did you look for something else?