ADRB3 antibody

Catalog No. ABIN317855

Product Details anti-ADRB3 Antibody

Target: ADRB3 (Adrenergic, beta-3-, Receptor (ADRB3))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRB3 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: AR-β3 antibody detects endogenous levels of AR-β3 protein.(region surrounding Leu291)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ADRB3

Target: ADRB3 (Adrenergic, beta-3-, Receptor (ADRB3))

Alternative Name: beta-3 Adrenergic Receptor (ADRB3 Products)

Synonyms: BETA3AR antibody, Adrb-3 antibody, ADRB antibody, BAR3 antibody, B3AR antibody, GPCR antibody, im:7154935 antibody, si:ch211-215f19.1 antibody, zgc:194843 antibody, zgc:194852 antibody, adrenoceptor beta 3 antibody, adrenergic receptor, beta 3 antibody, adrenoceptor beta 3a antibody, adrenoceptor beta 3b antibody, ADRB3 antibody, Adrb3 antibody, adrb3a antibody, adrb3b antibody

Background: The members of the G-protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. β-adrenergic bound to adrenaline activates adenylyl cyclase, while α2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. Like the α2-adrenergic receptor, serotonin receptor functions are also mediated by G proteins that inhibit the activity of adenylyl cyclase. The serotonin receptors have been classified into several categories and they are designated 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6 and 5-HT7. The 5-HT1 receptors have further been subdivided into 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, 5-HT1E and 5-HT1F receptors.Synonyms: ADRB3, ADRB3R, B3AR, Beta-3 adrenoceptor

Molecular Weight: approx. 36 kDa

Gene ID: 155

NCBI Accession: NP_000016

UniProt: P13945

Pathways: cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Brown Fat Cell Differentiation