CD44 antibody

Catalog No. ABIN317946

This anti-CD44 antibody is a Rabbit Polyclonal antibody detecting CD44 in WB. Suitable for Human, Mouse and Rat.

Quick Overview for CD44 antibody (ABIN317946)

Target: CD44

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD44 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CD44 Antibody

Specificity: This antibody detects endogenous levels of CD44 protein.(region surrounding Glu702)

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CD44

Target: CD44

Alternative Name: CD44

Background: Cell adhesion molecules (CAMs) are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and play an important role in embryogenesis and development. HCAM (also designated CD44) is a member of the CAM family and participates in the progression of IgA nephropathy by binding hyaluronic acid and osteopontin. The colocalization of osteopontin in the bladder epithelium with αVβ3 integrin and HCAM suggests a role for HCAM in maintaining the integrity of the transitional epithelium by providing the sealing and adhesiveness needed for the impermeable state of the bladder. HCAM is closely related to the secretory phase of the normal menstrual cycle and its expression is decreased in hyperplasia and in cancer cases. Decreased HCAM expression may be functionally involved in the multiple mechanisms of the development and progression of endometrial lesions.Synonyms: CDw44, ECMR-III, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, LHR, MDU2, MDU3, MIC4, PGP-1, Phagocytic glycoprotein 1

Molecular Weight: approx. 90 kDa

Gene ID: 960

NCBI Accession: NP_000601

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling