IRF7 antibody (C-Term)

Catalog No. ABIN318755

This Rabbit Polyclonal antibody specifically detects IRF7 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for IRF7 antibody (C-Term) (ABIN318755)

Target: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IRF7 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects an epitope within the C-terminal of Human Interferon Regulatory Factor 7 (IRF7).

Purification: Affinity Chromatography.

Immunogen: 14 amino acid peptide sequence near the carboxy terminus of Human IRF7.

Isotype: IgG

Application Details

Application Notes: Western Blot: 1.0-2.0 μg/mL. This antibody detects a band of approximately 51 kDa in 293 whole cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IRF7

Target: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Alternative Name: IRF7

Background: IRF7 is a 54kD transcriptional activator of type I interferons (IFNalpha/beta) in response to local and systemic viral infection. IRF7 is mostly expressed by plasmacytoid dendritic cells (pDC), which differentiate in response to IFNs and virus infection. This then stabilizes the IRF7 protein, in turn leading to increased IFN production. Multiple IRF7 transcript variants have been identified, although their individual functions have not yet been established.Synonyms: IRF-7, Interferon regulatory factor 7

Gene ID: 3665

NCBI Accession: NP_001563

UniProt: Q92985

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagy