Dynamin 1 antibody (pSer778)

Catalog No. ABIN319106

The Sheep Polyclonal anti-Dynamin 1 antibody has been validated for WB. It is suitable to detect Dynamin 1 in samples from Human, Mouse, Rat, Dog, Cow and Chicken.

Quick Overview for Dynamin 1 antibody (pSer778) (ABIN319106)

Target: Dynamin 1 (DNM1)

Reactivity: Human, Mouse, Rat, Dog, Cow, Chicken

Host: Sheep

Clonality: Polyclonal

Conjugate: This Dynamin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Dynamin 1 Antibody

Binding Specificity: pSer778

Specificity: This antibody is specific for Dynamin when phosphorylated at serine 778.

Purification: Affinity chromatography

Immunogen: Synthetic phosphopeptide corresponding to an amino acid sequence within dynamin which includes phosphorylated Ser778.

Isotype: IgG

Application Details

Application Notes: Western Blot: 1: 1000, detects a band of approximately 95 kDa in rat hippocampus lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM HEPES, pH 7.5 containing 0.09 % Sodium Azide, 0.01 % Bovine Serum Albumin and 50 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Dynamin 1

Target: Dynamin 1 (DNM1)

Alternative Name: Dynamin-1

Background: Dynamin is a phosphoprotein expressed at nerve terminals, which plays an important role in the regulation of synaptic vesicle endocytosis. Cyclin dependent protein kinase 5 (cdk5) has been shown to phosphorylate serine 774 and 778 in vivo. Dephosphorylation of these residues is essential for endocytosis of synaptic vesicles.Synonyms: DNM, DNM1

Gene ID: 140694

NCBI Accession: NP_542420

UniProt: P21575

Pathways: Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling