AMBP antibody

Catalog No. ABIN319500

Product Details anti-AMBP Antibody

Target: AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

Reactivity: Human

Host: Sheep

Clonality: Polyclonal

Conjugate: This AMBP antibody is un-conjugated

Application: Enzyme Immunoassay (EIA), Immunodiffusion (ID)

Specificity: This antibody recognises human alpha-1-Microglobulin. No cross-reactivity is observed with Urine Albumin, Retinol binding protein or beta-2-Microglobulin. It does Not react with Rat.

Purification: Purified IgG prepared by affinity chromatography on Protein G

Immunogen: Highly pure human alpha-1-microglobulin, prepared from the urine of patients with chronic renal proteinuria (Molecular Weight 25-30 kD).

Isotype: IgG

Application Details

Application Notes: ELISA (1/500-1/1000). Immunodiffusion.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 5.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for AMBP

Target: AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

Alternative Name: AMBP (AMBP Products)

Synonyms: A1M antibody, EDC1 antibody, HI30 antibody, IATIL antibody, ITI antibody, ITIL antibody, ITILC antibody, UTI antibody, ambp antibody, MGC64242 antibody, AMBP antibody, DKFZp470D2211 antibody, AI194774 antibody, ASPI antibody, HI-30 antibody, Intin4 antibody, Itil antibody, ambpl antibody, zgc:66321 antibody, alpha-1-microglobulin/bikunin precursor antibody, alpha-1-microglobulin/bikunin precursor L homeolog antibody, alpha 1 microglobulin/bikunin antibody, AMBP antibody, Ambp antibody, ambp.L antibody, ambp antibody

Background: Alpha(1)microglobulin/bikunin precursor specifically interacts with the ORF3 protein of hepatitis E virus and has a direct role in enhancing alpha(1)microglobulin export from the hepatocyte. Bikunin has a role in downregulating PI3 kinase and suppressing tumor invasiveness and metastasis in ovaran cancer cells. I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin. Interacts with FN1Synonyms: Alpha-1 microglycoprotein, Alpha-1-microglobulin, Bikunin, Complex-forming glycoprotein heterogeneous in charge, EDC1, HCP, HI-30, ITI-LC, ITIL, Inter-alpha-trypsin inhibitor light chain, Trypstatin, Uronic-acid-rich protein

Gene ID: 259

NCBI Accession: NP_001624

UniProt: P02760