Amylin/DAP antibody (AA 2-7)

Catalog No. ABIN334637

The Chicken Polyclonal anti-Amylin/DAP antibody is suitable to detect Amylin/DAP in samples from Human. It has been validated for WB and ELISA.

Quick Overview for Amylin/DAP antibody (AA 2-7) (ABIN334637)

Target: Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))

Reactivity: Human

Host: Chicken

Clonality: Polyclonal

Conjugate: This Amylin/DAP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Amylin/DAP Antibody

Binding Specificity: AA 2-7

Purpose: Anti-IAPP | Human IAPP (amylin) 1-37, specific for the native hormone having a disulphide-bridge between Cys2-Cys7

Cross-Reactivity (Details): Human
Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Predicted Reactivity: Primates,mouse,rat,dog,seal,Chinese hamster

Purification: Purified,total IgY

Immunogen: Synthetic peptide corresponding to the human the 37 residue IAPP also known as amylin. The IAPP/amylin peptide contains a disulphide-bridge between Cys2-Cys7 Amino acid sequence: KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY (disulphide link between Cys2-Cys7)

Isotype: IgY

Application Details

Application Notes: 1:1000 (WB), 1:1000 (ELISA)

Comment:

antibody is recognizing trimer, dimer and monomer human IAPP

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Purified,total IgY (chicken egg yolk immunoglobulin) in PBS pH 8. Contains 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube

Storage: -20 °C

Storage Comment: Store lyophilized/reconstituted at -20°C, once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

Target Details for Amylin/DAP

Target: Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))

Alternative Name: IAPP

Background: Amylin, or Islet Amyloid Polypeptide (IAPP) P10997, is a 37-residue peptide hormone secreted by pancreatic beta-cells at the same time as insulin (in a roughly 1:100 amylin:insulin ratio). Islet, or insulinoma, almyloid polypeptide (IAPP, or amylin) is commonly found in pancreatic islets of patients suffering diabetes mellitus type 2, or harboring an insulinoma. While the association of amylin with the development of type 2 diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Recent results suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzherimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the deleopment of type 2 diabetes.

Molecular Weight: 3.9 kDa

Pathways: Hormone Activity, Feeding Behaviour