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PARK7/DJ1 antibody

PARK7 Reactivity: Human, Mouse, Dog, Xenopus laevis WB, IHC, IP, ICC, IHC (fro) Host: Mouse Monoclonal 12B11F8 unconjugated
Catalog No. ABIN335354
  • Target See all PARK7/DJ1 (PARK7) Antibodies
    PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
    Reactivity
    • 93
    • 70
    • 51
    • 8
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Dog, Xenopus laevis
    Host
    • 100
    • 14
    • 2
    • 1
    Mouse
    Clonality
    • 94
    • 23
    Monoclonal
    Conjugate
    • 71
    • 13
    • 9
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PARK7/DJ1 antibody is un-conjugated
    Application
    • 95
    • 43
    • 31
    • 30
    • 26
    • 21
    • 20
    • 14
    • 14
    • 13
    • 5
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    Human, mouse, dog and Xenopus laevis.
    Purification
    Serum
    Immunogen
    12B11F8 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with a synthetic peptide corresponding to amino acid residues 779-793 of human plakophilin-3 coupled to keyhole limpet hemocyanin. (KLHRDFRAKGYRKED).
    Clone
    12B11F8
    Isotype
    IgG1
    Top Product
    Discover our top product PARK7 Primary Antibody
  • Application Notes
    12B11F8 reacts with an epitope located between residues 779-793 in human plakophilin-3. 12B11F8 is suitable for immunocytochemistry (methanol-fixed cells), immunohistochemistry on frozen tissues, immunoprecipitation and Western blot detection. For optimal results, fixed cells or tissues should be treated with 0.2% Triton-X 100 for 5 min. prior to incubation with primary antibody. Optimal antibody dilution should be determined by titration, recommended range is 1:25 - 1:200 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.
    Restrictions
    For Research Use only
  • Storage
    4 °C
  • Bonné, Gilbert, Hatzfeld, Chen, Green, van Roy: "Defining desmosomal plakophilin-3 interactions." in: The Journal of cell biology, Vol. 161, Issue 2, pp. 403-16, (2003) (PubMed).

    Bonné, van Hengel, Nollet, Kools, van Roy: "Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells." in: Journal of cell science, Vol. 112 ( Pt 14), pp. 2265-76, (1999) (PubMed).

  • Target
    PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
    Alternative Name
    PARK7 / DJ-1 (PARK7 Products)
    Synonyms
    DJ-1 antibody, DJ1 antibody, CAP1 antibody, Dj1 antibody, SP22 antibody, dj1 antibody, zgc:103725 antibody, park7b antibody, park7 antibody, park7a antibody, Parkinsonism associated deglycase antibody, Parkinson disease (autosomal recessive, early onset) 7 antibody, parkinson protein 7 antibody, parkinson protein 7 S homeolog antibody, parkinson protein 7 L homeolog antibody, PARK7 antibody, Park7 antibody, park7 antibody, park7.S antibody, park7.L antibody
    Background
    Plakophilin-3 is an Armadillo-like protein present in nuclei and desmosomes of epithelial cells [1]. The expression pattern of this protein seems to be largely restricted to epithelial cell types. Plakophilin-3 can be detected along cell borders in a punctuate staining pattern typical for desmosomal proteins. In addition to the desmosomal immunolocalisation, immunostaining was observed as bright nuclear speckles. Thus, like plakophilin-1 and-2, plakophilin-3 displays a dual intracellular localisation in the desmosomal plaque and in the cell nucleus, and therefore is probably involved in signal transduction pathways between the plasma membrane and the nucleus. The human protein has a predicted molecular mass of 87 kD.
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport
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