ABCA4 antibody (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4) (AA 2250-2263)

Details for Product anti-ABCA4 Antibody No. ABIN343052
Target
Binding Specificity
AA 2250-2263
10
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
35
13
8
4
4
2
2
1
1
1
Host
Goat
27
7
6
Clonality
Polyclonal
Conjugate
This ABCA4 antibody is un-conjugated
2
2
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
27
16
13
2
2
1
1
1
Options
Purpose ABCA4
Immunogen Synthetic peptide C-KQQTESHDLPLHPR from the C-terminus of human ABCA4 (NP_000341.2).
Type of Immunogen: Synthetic peptide
Blocking Peptide Blocking peptide for this product available: ABIN369349
Sequence KQQTESHDLP LHPR
Isotype IgG
Predicted Reactivity Human, Dog
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Grade Verified
Target
Alternative Name ABCA4 (ABCA4 Antibody Abstract)
Background ABCA4, ATP-binding cassette, sub-family A (ABC1), member 4, ABC10, ABCR, ARMD2, CORD3, DKFZp781N1972, FFM, RMP, RP19, STGD, STGD1, ATP binding cassette transporter, ATP-binding cassette, sub-family A member 4, ATP-binding transporter, retina-specific, retina-specific ABC transporter, rim protein
Gene ID 24
NCBI Accession NP_000341
UniProt P78363
Application Notes Peptide ELISA: antibody detection limit dilution 1:8000.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20°C, with minimal freeze/thawing. A working aliquot may be refrigerated at 4°C for a few weeks and still remain viable.
Images
Image no. 1 for anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) (AA 2250-2263) antibody (ABIN343052) Immunoblot of retina and RPE homogenates from BALB/c, Abca4−/−, and RPE-Abca4-Tg/Abca...
Image no. 2 for anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) (AA 2250-2263) antibody (ABIN343052) Immunoblot for ABCA4 protein using neural retina and RPE/eyecup homogenates loaded as...
Product cited in: McClements, Barnard, Issa, MacLaren: "Assessment of AAV Dual Vector Safety in theAbca4-/- Mouse Model of Stargardt Disease." in: Translational vision science & technology, Vol. 9, Issue 7, pp. 20, 2020 (PubMed).

McClements, Barnard, Singh, Charbel Issa, Jiang, Radu, MacLaren: "An AAV Dual Vector Strategy Ameliorates the Stargardt Phenotype in Adult Abca4-/- Mice." in: Human gene therapy, Vol. 30, Issue 5, pp. 590-600, 2019 (PubMed).

Lenis, Hu, Ng, Jiang, Sarfare, Lloyd, Esposito, Samuel, Jaworski, Bok, Finnemann, Radeke, Redmond, Travis, Radu: "Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 47, pp. E11120-E11127, 2019 (PubMed).