ABCA4 antibody (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4)

Details for Product anti-ABCA4 Antibody No. ABIN361347
Antigen
Reactivity
Cow (Bovine)
44
20
12
5
5
4
3
1
1
1
Host
Mouse
36
8
7
Clonality (Clone)
Monoclonal ()
Conjugate
This ABCA4 antibody is un-conjugated
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
35
20
16
3
2
1
1
1
Options
Immunogen Partially purified bovine 220-kDa disc rim protein
Clone 3F4
Isotype IgG
Specificity Specific for ABCA4
Cross-Reactivity Cow (Bovine), Human, Mouse (Murine), Xenopus laevis
Purification Protein G purified culture supernatant
Antigen
Alternative Name ABCA4 (ABCA4 Antibody Abstract)
Background ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) is a member of the superfamily of ATP-binding cassette (ABC) transporters (Illing et al., 1997). ABC proteins transport various molecules across extra- and intracellular membranes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration (Wiszniewski et al., 2003). Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) (Molday et al., 2000). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3) (Klevering et al., 2005). Anti-ABCA4 Immunohistochemical staining of adult mouse retina showing specific immunolabeling of the ABCA4 protein. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA.
Molecular Weight '220 kDa
Gene ID 11304
UniProt O35600
Application Notes Recommended Dilution: WB: 1:1000 IHC: 1:100 Quality Control: Western blots performed on each lot.
Restrictions For Research Use only
Format Liquid
Buffer 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
Storage -20 °C
Supplier Images
Image no. 1 for anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) antibody (ABIN361347) Immunohistochemical staining of adult mouse retina showing specific immunolabeling of...