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ABCA4 antibody (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4) Primary Antibody

ABCA4 Reactivity: Cow IHC, WB Host: Mouse Monoclonal 3F4 unconjugated
Catalog No. ABIN361347
$541.20
Plus shipping costs $45.00
100 μL
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  • Target
    ABCA4
    Reactivity
    Cow
    • 34
    • 12
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Host
    Mouse
    Clonality
    Monoclonal
    Conjugate
    This ABCA4 antibody is un-conjugated
    • 24
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Immunohistochemistry (IHC), Western Blotting (WB)
    • 24
    • 17
    • 13
    • 1
    • 1
    • 1
    Specificity
    Specific for ABCA4
    Cross-Reactivity
    Cow (Bovine), Human, Mouse (Murine), Xenopus laevis
    Purification
    Protein G purified culture supernatant
    Immunogen
    Partially purified bovine 220-kDa disc rim protein
    Clone
    3F4
    Isotype
    IgG
  • Application Notes
    Recommended Dilution: WB: 1:1000 IHC: 1:100 Quality Control: Western blots performed on each lot.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    Storage
    -20 °C
  • Target
    ABCA4
    Alternative Name
    ABCA4 (ABCA4 Antibody Abstract)
    Synonyms
    ABC10, ABCR, ARMD2, CORD3, FFM, RMP, RP19, STGD, STGD1, AW050280, Abc10, Abcr, D430003I15Rik, RmP, abcr, ffm, rmp, rp19, stgd, abc10, armd2, cord3, stgd1, zgc:91823, ATP binding cassette subfamily A member 4, ATP-binding cassette, sub-family A (ABC1), member 4, ATP binding cassette subfamily A member 4 L homeolog, ATP-binding cassette, sub-family A (ABC1), member 4a, ABCA4, Abca4, abca4, abca4.L, abca4a
    Background
    ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) is a member of the superfamily of ATP-binding cassette (ABC) transporters (Illing et al., 1997). ABC proteins transport various molecules across extra- and intracellular membranes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration (Wiszniewski et al., 2003). Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) (Molday et al., 2000). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3) (Klevering et al., 2005). Anti-ABCA4 Immunohistochemical staining of adult mouse retina showing specific immunolabeling of the ABCA4 protein. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA.
    Molecular Weight
    '220 kDa
    Gene ID
    11304
    UniProt
    O35600
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